I saw this on Tumblr and absolutely couldn’t pass it up. All I can find about this image is that it comes from the famous Farm Security Administration photos documenting the depression.
This appears to have started life as another wagon, maybe even a delivery van or bus but has been repaired beyond recognition. I did a reverse image lookup and found a larger version (shown here). Comments on THIS PAGE indicates it started as a Studebaker School Bus but was probably converted into a dwelling.
Click the photo for full-size image.